scaleup effects on flow patterns in the high shear mixing

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scaleup effects on flow patterns in the high shear mixing

Scale-up effects on flow patterns in the high shear mixing ...

Oct 11, 2013 1. Introduction. High shear mixers, also known as high intensity mixers (Manjunath et al., 2003), are widely used for the powder processing.They can be used for simple mixing, in particular of cohesive materials, since they exert a high local shear on the powder which breaks down the small aggregates (Harnby, 1997), or for more complex operations which involve both solids and liquids.

Scale-up effects on flow patterns in the high shear mixing ...

Scale-up effects on flow patterns in the high shear mixing of cohesive powders Mauro Cavinato, Riccardo Artoni b , Massimo Bresciani c , Paolo Canu a , Andrea C. Santomaso a, *

HIGH SHEAR WET GRANULATION: PROCESS

Scale-up effects on the powder flow patterns were investigated as well. The research activities were mainly carried out in: - Dipartimento di Principi e Impianti per l‘Ingegneria Chimica, Università degli Studi di ... CHAPTER 6 - Predicting scale up effects on flow pattern in high shear mixing of

Evaluating scale-up rules of a high-shear wet granulation ...

This work aimed to evaluate the commonly used scale-up rules for high-shear wet granulation process using a microcrystalline cellulose-lactose-based low drug loading formulation. Granule properties such as particle size, porosity, flow, and tabletability, and tablet dissolution were compared across

Scale-Up Of Rotor-Stator Equipment

By contrast, scale-up of high shear devices such as ... while mixing to determine the effects of the fluid phys-ical properties on power draw. The most effective method of doing this is to incorporate a torque trans- ... viscosities the flow patterns in the gap will not exhibit

HIGH SHEAR WET GRANULATION: PROCESS

Scale-up effects on the powder flow patterns were investigated as well. The research activities were mainly carried out in: - Dipartimento di Principi e Impianti per l‘Ingegneria Chimica, Università degli Studi di ... CHAPTER 6 - Predicting scale up effects on flow pattern in high shear mixing of

Scale-up of high shear mixer-granulator based on discrete ...

Feb 01, 2013 For developing a scale-up method based on the kinematic and dynamic similarities of particle behavior, motion of particles in a commercial high shear mixer-granulator with different vessel sizes (2 to 112 L) were simulated using a three-dimensional discrete element method (DEM).Effects of the vessel size on the internal particle flow and the particle collision energy were analyzed.

Scale up of High Shear Mixers

Scale up of High Shear Rotor-Stator Mixers In virtually any application, scale up is a critical process that impacts your business in a multitude of ways, from proper planning of plant floor design and equipment configuration, to operating procedures, to the net operating-and capital-cost impact on the bottom line.

Scale-Up Of Rotor-Stator Equipment

By contrast, scale-up of high shear devices such as ... while mixing to determine the effects of the fluid phys-ical properties on power draw. The most effective method of doing this is to incorporate a torque trans- ... viscosities the flow patterns in the gap will not exhibit

Scale-up study of high-shear fluid-particle mixing based ...

The purpose of this work is to study the similarity behavior of high-shear fluid-particle interaction with numerical simulations. Specifically, we demonstrate the process in vessels with four-blade impellers. Through the study, we provide guidance for practices scaling from lab tests to industrial level, which is a major interest in industry when computer capacity is limited and large scale ...

Better understanding boosts mixer scale-up

Apr 10, 2008 At lower viscosities the flow patterns in the gap won’t exhibit simple shear flow and will become more turbulent — in which case turbulent energy dissipation may become more significant. Although scale-up using values of shear rate and tip speed work well in some applications involving agitators and stirrers, they aren’t necessarily ...

High shear mixers: A review of typical applications and ...

Jul 01, 2012 Constant rotor tip speed (ND) scale-up criterion was suggested for batch high shear mixing processes that depend on macro-scale quantities, based on their experimental results that self similar flow pattern, mean velocity, strain rate and turbulence intensity fields would be maintained in geometrically similar HSM units. 5.

(PDF) High shear mixers: A review of typical applications ...

High shear mixers: A review of typical applications and studies on power draw, flow pattern, energy dissipation and transfer properties ... The effect of stator geometry on the flow pattern and energy dissipation rate in a rotor–stator mixer. ... Comparison of Mixing Technologies for the Production of Concentrated Emulsions. By Louis Fradette ...

A Quality By Design Approach to Scale-Up of High Shear Wet ...

Jan 01, 2019 Abstract. High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in the literature. This review article discusses existing scale-up principles and categorizes the ...

PM0509 26 37 MIXING - PharmaManufacturing

To illustrate the effect of impeller geometry and scaleup on shear, let us assume that power per unit volume, P/V, is to be kept constant and equal ... Flow Pattern K avg K max Np Nq Rushton turbine Radial 12 145.7/m 5.75 0.80 45° pitched bladed ... travel through the high shear zone, then the average impeller shear rate dictates the process ...

Effect of Blade Speed on Granular Flow and Mixing in a ...

The effect of particle shape on mixing in a high shear mixer. ... Scale-up of agitated drying: Effect of shear stress and hydrostatic pressure on active pharmaceutical ingredient powder properties. ... Scale-up effects on flow patterns in the high shear mixing of cohesive powders. Chemical Engineering Science 2013, 102 , 1-9.

The Art and Science of Industrial Mixing ...

Typical components of mixing equipment, including tanks, motors, drives, seals, shafts, and impellers. Upon completion of this course you will be prepared to: Apply mixing fundamentals to your process applications. Understand the importance of flow patterns. Evaluate and quantify mixer performance for new or existing mixers using a Mixing ...

Application of the Discrete Element Method to Scale-Up of ...

Jan 01, 2019 Scale-up of high-shear granulation has been an important yet challenging issue in the pharmaceutical industries. A discrete element method (DEM) is a promising tool for the rational design and scale-up of high-shear granulation, because the internal properties such as particle flow and stress field, which are hard to measure experimentally, can be investigated.

Characterisation of Flow Pattern in a Rotor Stator High ...

Characterisation of Flow Pattern in a Rotor Stator High Shear Mixer Proceedings of European Congress of Chemical Engineering (ECCE-6) Copenhagen, 16-20 September 2007 Characterisation of Flow Pattern in a Rotor Stator High Shear Mixer A. Pacek, a M. Baker, b A. T. Utomo a aSchool of Chemical Engineering, University of Birmingham, B15 2TT ...

Scale-up effects on flow patterns in the high shear mixing ...

Scale-up effects on flow patterns in the high shear mixing of cohesive powders ... The aim was to propose a new and more detailed method for describing the complex powder rheology inside an high shear mixer using impeller torque, current consumption and particle image velocimetry (PIV) analysis. ... strongly affecting the powder flow patterns ...

Scale-up effects on flow patterns in the high shear mixing ...

Scale-up effects on flow patterns in the high shear mixing of cohesive powders; Italiano. Italiano; English ...

Characterisation of Flow Pattern in a Rotor Stator High ...

Characterisation of Flow Pattern in a Rotor Stator High Shear Mixer Proceedings of European Congress of Chemical Engineering (ECCE-6) Copenhagen, 16-20 September 2007 Characterisation of Flow Pattern in a Rotor Stator High Shear Mixer A. Pacek, a M. Baker, b A. T. Utomo a aSchool of Chemical Engineering, University of Birmingham, B15 2TT ...

Better understanding boosts mixer scale-up

Apr 10, 2008 At lower viscosities the flow patterns in the gap won’t exhibit simple shear flow and will become more turbulent — in which case turbulent energy dissipation may become more significant. Although scale-up using values of shear rate and tip speed work well in some applications involving agitators and stirrers, they aren’t necessarily ...

AGITATION AND MIXING OF FLUIDS - cvut

a ± axial-flow pattern, baffled vessel, b ± radial-flow pattern, baffled vessel, ... High shear stress impeller CVS 69 1038.1, .2 2 y 4 1 st variant h / d 0 ,1 d 2 / d 0 ,8 ... Scale-up of mixing processes. EXAMPLE: Blending efficiency of impellers

mixing of fluids - University of Babylon

flow perpendicular to the impeller’s rotation axis. Small blade, high-speed impellers are used to mix low to medium viscosity liquids. Figures 8-4 and 8-5, respectively, show the six-flat blade turbine and marine propeller-type agitators. Figure 8-6 shows flat blade turbines used to produce radial flow patterns perpendicular to the vessel wall.

Master - Chemical Processing

exist around a mixing impeller and in recir-culating flow patterns. As shear thickening implies, the apparent viscosity increases at higher shear rates. Many shear-depen-dent fluids are time independent, meaning that only the current shear rate affects the apparent viscosity. The viscosity of time-de-pendent non-Newtonian fluids not only

Solid Oral Dosage Forms Powder Blending - IKEV

– Excessive high shear mixing (air introduced during blending) – Settling effects • Dusting or particles in the air - fines accumulating at side or perimeter of drum/bin. • Arching or ‘rat holing’ - different angle of repose and cohesiveness of mix components leads to differences in sliding, mixing, and discharge pattern of mix ...

High Shear Mixers Scott Turbon Mixer

High Shear Mixers. For almost four decades, Scott Turbon has manufactured high-performance, long-lasting stainless steel high shear mixers for use in the food, cosmetic, biopharmaceutical, and chemical industries. Across North America, Scott Turbon Mixer is the premier choice for manufacturing a wide variety of consumer products, including ...

How computational fluid dynamics is applied to mixer ...

May 01, 2013 Flow pattern effects. While 2D modeling only gives a quick approximation of the mixing tank flow pattern in the vertical plane, it supports rapid decisions on impeller placement and number of impellers required, especially in low-viscosity blending applications. Modeling in 3D takes into account impeller geometry and its rotation.

Flow physics and mixing quality in a confined impinging ...

Apr 02, 2020 In this study, the flow pattern, turbulence characteristics, mixing quality, and residence time of a confined impinging jet mixer (CIJM) have been investigated via direct numerical simulations. To study the effects of the scale, three Reynolds numbers of 200, 600, and 1000 are examined.

Scale-up of high-solid enzymatic hydrolysis of steam ...

Aug 08, 2015 The importance of flow conditions during scale-up of high-solid enzymatic hydrolysis of steam-pretreated spruce was demonstrated by comparing hydrolysis rates between laboratory (2 L) and demonstration (4 m3) scale. A positive effect of increased agitation speed on the rate of enzymatic hydrolysis was found regardless of scale. Importantly, the hydrolysis rate was higher at the larger

Culturing Microalgae in Photobioreactors: Advanced ...

flow field Cells’ movements, light history Shear Stress High shear stress damages the cells Mass Transfer Access to the nutrient and remove O 2 Concentration Distribution Light intensity distribution inside the reactor In-depth knowledge of hydrodynamics/flow pattern in the bioreactors is the key for design and scale-up. Advanced diagnostic ...

MIXING - SlideShare

Mar 25, 2018 a) IMPELLER Impellers are mixing devices that provide a definite flow pattern in liquid during mixing, moving at various speeds. Liquids are mixed usually by impellers, which produce shear forces for inducing the necessary flow pattern in the mixing container. CLASSIFICATION Impeller exists in different forms. 1. Propeller 2. Turbine 3.